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Sortase A

Host Organism

Staphylococcus aureus

Type

Sortase

Sequence

MKKWTNRLMTIAGVVLILVAAYLFAKPHIDNYLHDKDKDEKIEQYDKNVKEQASKDKKQQAKPQIPKDKSKVAGYIEIPDADIKEPVYPGPATPEQLNRGVSFAEENESLDDQNISIAGHTFIDRPNYQFTNLKAAKKGSMVYFKVGNETRKYKMTSIRDVKPTDVGVLDEQKGKDKQLTLITCDDYNEKTGVWEKRKIFVATEVK

External Links

PDB ID: 1IJA
EC: 3.4.22.70
MEROPS: C60 sortase
UniProt ID: Q2FV99
NCBI accession: -

Substrate Specificity

P4
P3
P2
P1
P1'
P2'
L
P
X
T
G
G

Functions

  • Backbone terminal ligation
  • Specificity strigency: Prime-high, Nonprime-high

Expression Platform:

  • E. coli

Mutations:

-

Other Properties:

-

References:

  1. [1] Ton-That, H.; Mazmanian, S. K.; Alksne, L.; Schneewind, O. Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus. J. Biol. Chem. 2002, 277 , 7447-7452. (9) DOI: 10.1074/jbc.M109945200