Host Organism
Galerina marginata
External Links
EC:
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UniProt ID:
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NCBI accession:
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Substrate Specificity
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Functions
- Backbone terminal cyclization
- Specificity stringency: Prime-low, Nonprime-high
References:
- [1]
Luo, H.; Hong, S. Y.; Sgambelluri, R. M.; Angelos, E.; Li, X.; Walton, J. D. Peptide Macrocyclization Catalyzed by a Prolyl Oligopeptidase Involved in alpha-Amanitin Biosynthesis. Chem. Biol. 2014, 21 (12), 1610-1617. (Discovery, Recombinant expression)
DOI: 10.1016/j.chembiol.2014.10.015
- [2]
Czekster, C. M.; Ludewig, H.; McMahon, S. A.; Naismith, J. H. Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates. Nat Commun 2017, 8 (1), 1045. (Structure, Mechanism)
DOI: 10.1038/s41467-017-00862-4