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Sortase B

Host Organism

Staphylococcus aureus

Type

Sequence

MRMKRFLTIVQILLVVIIIIFGYKIVQTYIEDKQERANYEKLQQKFQMLMSKHQEHVRPQFESLEKINKDIVGWIKLSGTSLNYPVLQGKTNHDYLNLDFEREHRRKGSIFMDFRNELKNLNHNTILYGHHVGDNTMFDVLEDYLKQSFYEKHKIIEFDNKYGKYQLQVFSAYKTTTKDNYIRTDFENDQDYQQFLDETKRKSVINSDVNVTVKDKIMTLSTCEDAYSETTKRIVVVAKIIKVS

External Links

PDB ID: 1NG5
EC: -
MEROPS: -
UniProt ID: -
NCBI: -

Substrate Specificity

P4
P3
P2
P1
P1'
N
P
Q
T
N

Functions

-

Expression Platform:

  • E. coli

Mutations:

Other Properties:

-

References:

  1. [1] (Discovery) Bierne, H.; Garandeau, C.; Pucciarelli, M. G.; Sabet, C.; Newton, S.; Garcia-del Portillo, F.; Cossart, P.; Charbit, A. Sortase B, a new class of sortase in Listeria monocytogenes. J Bacteriol 2004, 186 (7), 1972-1982. DOI: 10.1128/jb.186.7.1972-1982.2004
  2. [2] (Structure) Zhang, R.; Wu, R.; Joachimiak, G.; Mazmanian, S. K.; Missiakas, D. M.; Gornicki, P.; Schneewind, O.; Joachimiak, A. Structures of sortase B from Staphylococcus aureus and Bacillus anthracis reveal catalytic amino acid triad in the active site. Structure 2004, 12 (7), 1147-1156. DOI: 10.1016/j.str.2004.06.001.
  3. [3] (Application) Wang, G.; Gao, Y.; Wang, H.; Wang, J.; Niu, X. Phloretin reduces cell injury and inflammation mediated by Staphylococcus aureus via targeting sortase B and the molecular mechanism. Appl Microbiol Biot 2018, 102 (24), 10665-10674. DOI: 10.1007/s00253-018-9376-8.