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PhPCY3

Host Organism

Pseudostellaria heterophylla (Miq.) Pax

Type

POP-like cyclase

Sequence

MTSSTFSKPLHYPPVRRDDSVVDDYFGVKIPDPYRWLEDPDSEETKEFVQNQIKLADSVLEECDSRDKIKKKITDFINFPRCGVPFKRGDKCFHFYNSGLQAQNVLHIQDDVEAKPEVLLDPNLIVNGKAGLHVHSVSEDAKYIAYGLPLGLTEWVTIKVMRIEDREILPDTLSWVKFSGCYWTHDCKGFFYCPYPPRNEAQEEDSETKTSTFDTSSSLNQTVSYHFLGTDQSEDILCWRDLENPLQHFKIDVTADGKYLLIYIHVSSGVMNKVYYVDLTTLPNGLEGYRGREDLLPFVKFIDDYDATYTAVANDDSVFIFLTNKDAPNNKLVRVDLNNPDIWTDVIPHSEKEVLESANAVNGNQLLVRYLSDVKHVLEVRDLESGSLLHRIPSGIGSVGGVNARREDSVVFFKFTSFLTPGIIYQCDLKDAVPQLKIFQESVVPEFDRSEFEVNQVFFPSKDGTKIPMFIVARKGISLDGSHPCELHGYGGFNINLMPNFSASRIVWLKHLGGVFCLPNIRGGGEYGDEWHKAGMLDKKQNVFDDFISAAEFLISNGYTAPTKLGIEGGSNGGLLVATCINQRPDLFACAMANCGVMDMLRFHKFTMGYLWTADYGCSEKEEDFNWLIKYSPLHNVRRPWEESENKQLQYPATMILAADHDDRVVPLHSFKLLATMQYLLCTTLEDSPQKNPLIARIECKASHFGRATMLQIEEVTDRYAFLAKAVNASWTD

External Links

PDB ID: -
EC: -
UniProt ID: -
NCBI: -

Substrate Specificity

P1
P1'
P
aromaticAA

Functions

  • Backbone terminal cyclization
  • Specificity stringency: Prime-low, Nonprime-high

Expression Platform:

  • E. coli

Mutations:

Other Properties:

-

References:

  1. [1] (Disccovery, Sequence, Activity) Qin, X.; Wang, F.; Xie, D.; Zhou, Q.; Lin, S.; Lin, W.; Li, W. Identification of a key peptide cyclase for novel cyclic peptide discovery in Pseudostellaria heterophylla. Plant Commun 2025, 101315. DOI: 10.1016/j.xplc.2025.101315